Most of our U.S. cattle harbor Moraxella
bovis in their respiratory or reproductive tracts, sometimes without being present in the
eye. Subsequently, when we administer the 1st dose of our better-developed
and broader spectrum M. bovis bacterin, we experience an amnestic memory response following the priming from initial respiratory or reproductive exposure.
Oil adjuvants are of benefit
when required. With 92% efficacy from the 1st dose and 96% from the 2nd,
we obviously don't need an oil adjuvant. There are several down sides to
oil adjuvants. One, widely known, consideration is a higher incidence of
injection site reactions such as granulomas and abscesses. A topic less
discussed and understood is the possibility of oil adjuvants exacerbating
endotoxin shock.
Dr. Lisle George of UC-Davis
reported, in the American Journal of Veterinary Research, that IBR virus
vaccines tend to inhibit pinkeye-fighting immune cells. He suggests not
using MLV IBR vaccines in the face of a pinkeye outbreak. He recommends
waiting until the break has cleared up. Bruce Addison (president of
Addison Biological Laboratory, Inc.) has said and believed for years that the
IBR virus colonizes in the ocular tissue and interferes with the immune response.
In some instances where our product was perceived to have failed, we've
discovered that the herd had subclinical or clinical IBR disease.
Note: IBR, Chlamydia and Mycoplasma can cause eye problems.
In one instance in Decorah, IA where we were investigating a perceived pinkeye
outbreak, post M/G vaccination, Bruce Addison noted classic buccal ulcers on the
mouth of several cows. He asked the veterinarian about any recent herd
history with BVD. The veterinarian confirmed the herd was being treated
for BVD. Bruce reminded him that the herd's immune system was probably compromised
and they could not be expected to properly respond to any vaccine.
No, true IBK is caused by Moraxella bovis.
The fly is a common mechanical vector that spreads the disease from animal to
animal. The tongue of the face fly looks much like a rasp under a
microscope. When flies feed off the lacrimal fluids at the eye, they
sometimes scratch the cornea. This initial lesion can reduce the eye's
defenses to disease and allow the infection to begin.
Administer the 2nd dose at least 30 days before
the onset of your normal pinkeye season challenge. This will allow the 2nd
dose time required to deliver a peak immune response.
You should receive protection for an entire season. You should booster 1
dose next year.
In most seasons you probably can but
its not
recommended because the bacterin is licensed as a two dose regimen. You
may be able to give one dose in herds that have not had a bad pinkeye
history. You should watch them closely and give the second dose if they
start breaking at the onset of any high challenge conditions (heat, dust,
flies). Give those that break another dose along with an appropriate
antibiotic to clear them up. Our bacterin stimulates IgG antibodies in the
lacrimal fluids directly proportional to those stimulated in the blood
serum. Within a couple of days, the eyes are bathed with toxin
neutralizing antibodies.
It's the safest M. bovis
bacterin ever licensed. Several years ago we completed a dose
safety study for the U.S.D.A.. We gave a dose 10-fold (20cc) the normal
2cc dose of our
product to calves. This excess is a risky dosage for any gram negative
product, but no animals became sick or went off their feed. Later we
discovered this 10 fold dose was in excess of the amount required to
demonstrate bacterin safety.
Yes. You should experience very little milk
reduction with our low free endotoxin levels. We don't use
preservatives. There's no milk withdrawal. Vaccinating during any
stage of gestation is fine.
